28.Acute tubular necrosis with ethylene glycol poisoning, microscopic
Chronic urate nephropathy leads to deposition of uric acid crystals in intersitium, forming tophi with surrounding foreign body inflammation, mononuclear cell infiltrates, and fibrosis. The long, needle-shaped crystals form the pale mass shown here at high magnification. Patients with hyperuricemia may also have nephrolithiasis with uric acid stones.