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Explain of Hepatic Pathology

67.Alpha-1-antitrypsin deficiency, liver, PAS stain, microscopic

The periportal red hyaline globules seen here with periodic acid-Schiff (PAS) stain are characteristic for alpha-1-antitrypsin deficiency (a person with homozygous pi-ZZ genotype) The globules are intrahepatic collections of alpha-1-antitrypsin that is not being excreted from the hepatocytes. This may eventually lead to a macronodular cirrhosis. These patients are also prone to develop panlobular emphysema of lungs.

（本图片资料来源自美国犹他大学）